Dear Rahul Sir, no, that will not happen as in common practice you don't consider the eligibility of ESIC on commission or incentive, but you have to pay the contribution on the actual gross.
Example of ESIC Calculation
For example, if a person has a gross salary of 20,000/- in the normal course, and in a month he gets a commission of, say, 10,000, then the gross salary calculates to be 30,000/-. In such a case, ESIC must be deducted on 30,000/-. Just because an employee got a commission in one month doesn't mean that you should opt that employee out of ESIC.