What I understand is that your wife is interested in taking up some small home-based business, which is part-time or with flexible timings, does not require much capital, and has little risk or responsibility. One can understand her desire, as everyone wants to be productive, earn extra income, and avoid being idle or unemployed.
Options for Home-Based Businesses
There are several options available, but all depend on personal traits, attitude, skills, and level of qualification. Also, it requires a lot of patience, and progress may be slow. For example, she can become a Financial (Income Tax) or Insurance consultant, a child counselor; she can run a creche or nursery at home; or take tuitions; arranging home-cooked tiffin service for office employees, etc.
A lot depends on the person's profile and personality traits, interests, and levels of business acumen. Your location is not given, which again is a constraint in giving a proper suggestion.
Warm regards.