Nowadays you have a system of online registration at
Sun Java System Application Server - Server Running. You can register yourself online with your employer code for ESIC. Fill in the employee details, upload the images and you will be provided the ESIC numbers for respective employees.
At the same time you can submit the forms to ESIC office. The ESIC office will give the acknowledgement of receipt of the forms and they will ask you to collect the ESIC cards of employees in a stipulated time period. On the given date collect the cards from ESIC office and make the cards available to the employees.