Sandeep,
Like so many, you also pose a very general question. Hence, it becomes difficult to answer. I would say that it all depends upon what job you are seeking. I started out as an Electrical Engineer, changed my field to Industrial Engineering. Then, I had no problem moving from Engineering to FMCG. I got a break to teach part-time while working for an FMCG company; I also did my MSc while working. Then I moved to teaching without a problem (All in the UK). Similarly, I know of people in marketing who have moved from Hewlett Packard to Adobe, Adobe to Symantec, and from Symantec to Avaya (a telecom firm). So, like Sam has said, it all depends upon what you can offer. Have a nice weekend.
Simhan